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Each episode of the Physiological Reviews podcast features commentary and discussion of newly published articles in the journal, which provides state-of-the-art, comprehensive, and high-impact coverage of timely issues in the physiological and biomedical sciences. Physiological Reviews articles appeal to physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with special interest in pathophysiology. The journal is very useful in teaching and research because it provides non-biased and clearly written updates on important developments.
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4 days ago
4 days ago
In the episode, Dr. Willis K. “Rick” Samson (Saint Louis University School of Medicine) interviews lead author Dr. Eric Lazartigues (Louisiana State University Health Sciences Center) about the recent Review by Chhabra et al. on the latest discoveries related to the role of ACE2 in glucose homeostasis and regulation of metabolism. What are the consequences, in terms of pancreatic function and glucose homeostasis, for ACE2 knockout animals compared to animals used in overexpression studies? Listen as we discuss skeletal muscle effects related to changes in body weight, effects on intestinal absorption and the microbiome, as well as potential clinical applications of ACE2 therapies. What advice does Dr. Lazartigues offer to early career researchers about how to pursue their good ideas? Listen to find out.
Kavaljit H. Chhabra, Robin Shoemaker, Chandana B. Herath, Merlin C. Thomas, Catalin M. Filipeanu, and Eric Lazartigues Molecular Dissection of the Role of ACE2 in Glucose Homeostasis Physiological Reviews, published February 7, 2025. DOI: 10.1152/physrev.00027.2024