Physiological Reviews Podcast

Neurobiology of Parenting and Infant-Evoked Aggression

In the episode, Dr. Sadis Matalon (University of Alabama Birmingham) interviews Dr. Catherine Dulac (Howard Hughes Medical Institute, Center for Brain Science, Harvard University) about the new Review in Physiological Reviews by Kaplan et al., which explores the neural basis of the complex social behavior of parenting. Parenting behavior is absolutely essential for the development of human beings and animal species. All humans and animals will experience the impact of parenting behavior on their lives, and parenting behavior is far more complex than simply the care of others. Parenting behavior is a unique physiological state that affects infant-to-adult interactions and adult-to-adult interactions, as well as a wide range of physiological changes related to food intake, sleep, and mood. We discuss essential questions related to the prevalence of postpartum depression disorder, genetic and environmental factors affecting the control of parenting behavior, and whether parenting behavior can improve over time with experience. Listen to this fascinating conversation to learn more.

 

Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman, and Catherine Dulac The neurobiology of parenting and infant-evoked aggression Physiological Reviews, published October 25, 2024. DOI: doi.org/10.1152/physrev.00036.2023

Proteomics of the Heart

In the episode, Dr. Carol Ann Remme (University of Amsterdam) and Dr. Sadis Matalon (University of Alabama Birmingham) interview Dr. Jenny Van Eyk (Cedars-Sinai) about the Review in Physiological Reviews by Karpov et al. that dives into proteomics of the heart. Given that proteins are the building blocks of life, studying only genetic data or RNAseq data may offer researchers a somewhat narrow view. Proteomics looks broader, and broader is better, according to Dr. Van Eyk. However, this means that rigor at the proteomic technology level is critically important. Because the field of proteomics offers many different tools, using proteomics to study the heart necessitates matching the research question to the right tool. Dr. Van Eyk encourages researchers to develop a well-defined research question and then match it to the proteomics technology that is most appropriate, so that the output is as useful as possible. Pushing research to new frontiers allows researchers to find discoveries they never expected. Listen now and learn more.

 

Oleg A. Karpov, Aleksandr Stotland, Koen Raedschelders, Blandine Chazarin, Lizhuo Ai, Christopher I. Murray, Jennifer E. Van Eyk Proteomics of the Heart Physiological Reviews, published April 9, 2024. DOI: doi.org/10.1152/physrev.00026.2023

Neurobiology and Systems Biology of Stress Resilience

What are the biological, neural, and psychological mechanisms of resilience to trauma, stress, and adversity? In this episode, Dr. Jan Born (University of Tübingen) interviews Dr. Raffael Kalisch (Leibniz Institute for Resilience Research) about the open access Review in Physiological Reviews by Kalisch et al. By unraveling the protective mechanisms of stress resilience, the authors hope to find new and better ways to improve therapies for stress-related disorders such as anxiety, depression, and post-traumatic stress disorder. Is there a unifying theory of stress resilience? Listen to this engaging conversation to find out.

 

Raffael Kalisch, Scott J. Russo, and Marianne B. Müller Neurobiology and systems biology of stress resilience Physiological Reviews, published May 15, 2024. DOI: 10.1152/physrev.00042.2023

Xenotransplantation from Genetically Modified Pigs to Humans

In our latest episode, Physiological Reviews Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews authors Dr. Leigh Peterson (Executive Vice President for Product Development and Xenotransplantation at United Therapeutics Corporation) and Professor Sir Magdi Yacoub (Professor of Cardiothoracic Surgery at the National Heart and Lung Institute at Imperial College London, and Founder and Director of Research at the Harefield Heart Science Centre and Aswan Heart Centre). The authors have published a comprehensive review on xenotransplantation. Listen as they discuss the steps necessary to immunologically modify pigs to avoid acute rejection and minimize chronic rejection, as well as the main differences between the GalSafe and the 10GE pigs described in the article. Given that the American Physiological Society launched their Women’s Health Research Initiative in spring 2024, we discuss how xenotransplantation and women’s health research are connected. What are the next important developments in this field? Listen to find out more.

 

Leigh Peterson, Magdi Yacoub, David Ayares, Kazuhiko Yamada ,Daniel Eisenson, Bartley P. Griffith, Muhammad Mohiuddin, Will Eyestone, J. Craig Venter, Ryszard T. Smolenski, and Martine Rothblatt Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review Physiological Reviews, published June 7, 2024. DOI: 10.1152/physrev.00041.2023

Community-Acquired Bacterial Coinfections and COVID-19

In our latest episode, Dr. Farrah Kheradmand (Baylor College of Medicine) interviews Dr. Kevin Harrod (University of Alabama at Birmingham) about his article by Patton et al. on community-acquired bacterial coinfections and COVID-19. In the early days of the pandemic when physicians were treating critically ill COVID patients, there was no standard definition for bacterial coinfections in this cohort. However, as the field has moved forward with understanding how bacterial coinfections contribute to the mortality of COVID patients, Dr. Harrod and co-authors have worked to refine the definition of bacterial coinfections to provide a more unified way to report the prevalence of this important clinical problem. While it is often necessary to treat critically ill hospitalized COVID patients with antibiotics before sampling or culture results, Dr. Harrod and co-authors identify that this may mask the true prevalence of bacterial coinfections. Listen as Dr. Kheradmand and Dr. Harrod discuss linkages between carriage, viral infection, and secondary bacterial infections, as well as the pathophysiological ways that fungi may coinfect COVID patients. Are patients with underlying cystic fibrosis more prone to COVID infection? Listen now to learn more.

 

Michael John Patton, Amit Gaggar, Matthew Might, Nathaniel Erdmann, Carlos J. Orihuela, and Kevin S. Harrod Community-acquired bacterial coinfections and COVID-19 Physiological Reviews, published October 16, 2023. DOI: 10.1152/physrev.00010.2023

Sex Differences in Blood Pressure Regulation and Hypertension

The topic of hypertension is of paramount clinical importance as a significant risk factor for cardiovascular disease, myocardial infarction, stroke, and kidney disease. Sex differences in blood pressure regulation play a major role in the pathophysiology of hypertension. In the episode, Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Thu Le (University of Rochester) about her new Review in Physiological Reviews on the renal, hemodynamic, and hormonal mechanisms of sexual dimorphism in blood pressure homeostasis. We discuss sex chromosome effects, hormonal changes, potential sex differences related to innate and adaptive immunity, and the clinical relevance of animal models to develop new therapeutic targets. Listen now and learn more.

 

Erika R. Drury, Jing Wu, Joseph C. Gigliotti, Thu H. Le Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms Physiological Reviews, published October 16, 2023. DOI: 10.1152/physrev.00041.2022

Amyloid beta-Peptide and Oxidative Stress in Alzheimer Disease Pathogenesis

In this episode of The Physiological Reviews Podcast, Professor Giovanni Mann (King’s College London) interviews authors Prof. Marzia Perluigi (Sapienza University of Rome) and Prof. D. Allan Butterfield (University of Kentucky) about their recently published Review on the oxidative stress hypothesis of Alzheimer Disease. The authors provide a comprehensive overview of amyloid beta-peptide associated mechanisms, the use of redox proteomics to define roles of lipid and protein oxidation, and the antioxidant strategies utilized to modulate the progression of Alzheimer Disease (AD) in order to improve the quality of life for individuals with this severe disorder. Prof. Perluigi explains that because the brain is particularly susceptible to free radical damage, it is likely that lipid peroxidation is among the initiating toxic events in AD pathophysiology, with amyloid deposits reacting with membrane lipids that in turn target other cellular components such as proteins and nucleic acid. Listen as we discuss the role of astrocytes in the pathogenesis of AD, as well as the utility of animal models to plan preclinical trials and clarify molecular mechanisms involved in neuropathology of AD. Come for the discussion of the role that oxidative stress plays in the pathogenesis of AD, and stay for the illuminating conversation about the paths Prof. Butterfield and Prof. Perluigi have followed in pursuing their research training and careers in science with enthusiasm, dedication, and willingness to develop international research collaborations in the field of redox biology and chemistry associated with Alzheimer Disease.

 

Marzia Perluigi, Fabio Di Domenico, and D. Allan Butterfield Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease Physiological Reviews, published July 19, 2023. DOI: 10.1152/physrev.00030.2022

AI in Physiology and Healthcare

As Sir Winston Churchill once said, “Where there is great power, there is great responsibility.” This is the overarching context of our latest episode about the future of artificial intelligence (AI) in physiology and healthcare. Listen as host Dr. Ryan Melvin (University of Alabama at Birmingham) interviews author Dr. James Zou (Stanford University) about the Review by Zhang et al. on “Leveraging Physiology and Artificial Intelligence to Deliver Advancements in Healthcare AI in Physiology and Healthcare.” The authors discuss an important transition in AI –the shift from model development to model deployment, while keeping at the forefront the goal of achieving positive real-world impacts by using AI in healthcare workflows. Zou and co-authors identify 3 key factors in this gap between development and deployment: ensuring AI works reliably and robustly across diverse populations, ensuring the financial sustainability of AI models, addressing new regulatory challenges for AI algorithms. FDA regulators are presented with unique challenges regarding how to continuously evaluate and monitor AI algorithms, while still allowing developers to update algorithms in a relatively frictionless way that ensures algorithms’ behavior is safe and robust. Does AI face a generalizability crisis? According to Dr. Zou, this is an ongoing issue. Instructive fine-tuning, which is intended to make iterative large language models safer, can sometimes lead to surprising AI behavior changes. On the topic of AI and authorship, the experts acknowledge that it is becoming increasingly difficult to distinguish if text is written by AI or by humans, as AI becomes more aligned with human behaviors. This may present unique opportunities, according to Dr. Zou. There are many types of text where human authors would benefit from AI support, for example in generating code and figures, and improving writing quality and precision. In the end, however, humans must take final responsibility for the accuracy of all statements in scholarly articles. How can the medical field play a role in shaping the metrics by which we judge generative AI? Listen to find out.

Angela Zhang, Zhenqin Wu, Eric Wu, Matthew Wu, Michael P. Snyder, James Zou, and Joseph C. Wu Leveraging Physiology and Artificial Intelligence to Deliver Advancements in Healthcare Physiological Reviews, published July 19, 2023. DOI: 10.1152/physrev.00033.2022

The Molecular Athlete: Exercise Physiology from Mechanisms to Medals

What are the key physiological adaptations attained in exercise regimens used by elite athletes to achieve peak performance? In our latest episode of The Physiological Reviews Podcast, Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews author and Physiological Reviews Associate Editor Dr. Christoph Handschin (University of Basel, Switzerland) about the new Review by Furrer et al. As Dr. Handschin explains, the basis of all types of muscle adaptations is repeated contractions, but how this is done in terms of training intensity, volume, form, and frequency can dramatically affect training outcomes. Athletes and coaches try to develop the best strategies for training periodization for performance to peak at the time of competition. What roles do sleep, diet, and environment, such as altitude, play in enhancing (or diminishing) exercise performance? Listen as Dr. Matalon and Dr. Handschin discuss experimental and natural product-based performance enhancing substances, wearable devices for tracking exercise performance, and the genetic makeup of individuals that ultimately differentiates athletes from Olympic athletes.

 

Regula Furrer, John A. Hawley, and Christoph Handschin The molecular athlete: exercise physiology from mechanisms to medals Physiological Reviews, published April 23, 2023. DOI: 10.1152/physrev.00017.2022

Genome-wide Association Studies of Cardiovascular Disease

Genetics studies, including genome-wide association studies (GWAS), play an increasingly important role in physiology and pathophysiology studies of cardiovascular disease. Listen as Deputy Editor Dr. Carol Ann Remme interviews authors Prof. Jeanette Erdmann (University of Lübeck, Germany) and Prof. Connie Bezzina (Amsterdam University Medical Center, Netherlands) about their latest Review in Physiological Reviews by Walsh et al. GWAS are aimed at identifying genetic variants for specific traits, and it is essential to study genetic variants in order to understand an individual’s susceptibility to develop specific diseases. Understanding the genetic basis of a disease can lead to identification of therapeutic targets for clinical intervention. Listen as these experts discuss how GWAS can be applied to study both rare disorders, for example Brugada Syndrome, as well as common disorders such as myocardial infarction. The possibilities are numerous for GWAS, including the identification of novel pathophysiological insights into cardiovascular disease mechanisms, as well as (future) development of clinically applicable polygenic risk scores. Listen now to learn more.

 

Roddy Walsh, Sean J. Jurgens, Jeanette Erdmann, and Connie R. Bezzina Genome-wide association studies of cardiovascular disease Physiological Reviews, published April 18, 2023. DOI: 10.1152/physrev.00024.2022